{"id":1226,"date":"2019-07-23T17:09:29","date_gmt":"2019-07-23T14:09:29","guid":{"rendered":"https:\/\/xavron.com.ua\/?post_type=publications&#038;p=1226"},"modified":"2023-04-11T13:37:30","modified_gmt":"2023-04-11T10:37:30","slug":"gostre-poshkodzhennya-nyrok-i-edaravon-pry-gostromu-ishemichnomu-insulti-reyestr-insultu-fukuoka","status":"publish","type":"publications","link":"https:\/\/xavron.com.ua\/en\/publications\/gostre-poshkodzhennya-nyrok-i-edaravon-pry-gostromu-ishemichnomu-insulti-reyestr-insultu-fukuoka\/","title":{"rendered":"Acute Kidney Injury and Edaravone in Acute Ischemic Stroke: The Fukuoka Stroke Registry"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-502 size-thumbnail\" src=\"https:\/\/xavron.com.ua\/wp-content\/uploads\/2019\/07\/edaravon-i-gostra-nyrkova-nedostatnist-400x228.jpg\" alt=\"\" width=\"400\" height=\"228\" srcset=\"https:\/\/xavron.com.ua\/wp-content\/uploads\/2019\/07\/edaravon-i-gostra-nyrkova-nedostatnist-400x228.jpg 400w, https:\/\/xavron.com.ua\/wp-content\/uploads\/2019\/07\/edaravon-i-gostra-nyrkova-nedostatnist.jpg 755w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/p>\n<p><strong>Background:<\/strong>\u00a0A free radical scavenger, edaravone, which has been used for the\u00a0<a href=\"https:\/\/xavron.com.ua\/en\/acute-ischemic-stroke\/\" data-wpel-link=\"internal\">treatment of ischemic stroke<\/a>, was reported to cause acute kidney injury (AKI) as a fatal adverse event. The aim of the present study was to clarify whether edaravone is associated with AKI in patients with acute ischemic stroke.\u00a0<strong>Methods:<\/strong>\u00a0From the Fukuoka Stroke Registry database, 5689 consecutive patients with acute ischemic stroke who were hospitalized within 24 hours of the onset of symptoms were included in this study. A logistic regression analysis for the Fukuoka Stroke Registry cohort was done to identify the predictors for AKI. A propensity score\u2013matched nested case\u2013control study was also performed to elucidate any association between AKI and edaravone.\u00a0<strong>Results:<\/strong>\u00a0Acute kidney injury occurred in 128 of 5689 patients (2.2%) with acute ischemic stroke. A multivariate analysis revealed that the stroke subtype, the basal serum creatinine level, and the presence of infectious complications on admission were each predictors of developing AKI. In contrast, a free radical scavenger, edaravone, reduced the risk of developing AKI (multivariate-adjusted odds ratio [OR] .45, 95% confidence interval [CI] .30-.67). Propensity score\u2013matched case\u2013control study confirmed that edaravone use was negatively associated with AKI (propensity score\u2013adjusted OR .46, 95% CI .29-.74).\u00a0<strong>Conclusions:<\/strong>\u00a0Although AKI has a significant impact on the clinical outcome of hospital inpatients,\u00a0<a href=\"https:\/\/xavron.com.ua\/en\/\" data-wpel-link=\"internal\">edaravone<\/a>\u00a0has a protective effect against the development of AKI in patients with acute ischemic stroke.<\/p>\n","protected":false},"featured_media":502,"parent":0,"menu_order":0,"template":"","publ-cat":[33],"publ-tags":[53,246,247,248],"class_list":["post-1226","publications","type-publications","status-publish","has-post-thumbnail","hentry","publ-cat-when-stroke-en","publ-tags-edaravone","publ-tags-free-radical-scavenger","publ-tags-ischemic-stroke","publ-tags-kidney-injury"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Acute Kidney Injury and Edaravone in Acute Ischemic Stroke: The Fukuoka Stroke Registry - Xavron<\/title>\n<meta name=\"description\" content=\"Background:\u00a0A free radical scavenger, edaravone, which has been used for the\u00a0treatment of ischemic stroke, was reported to cause acute kidney injury (AKI)\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/xavron.com.ua\/en\/publications\/gostre-poshkodzhennya-nyrok-i-edaravon-pry-gostromu-ishemichnomu-insulti-reyestr-insultu-fukuoka\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Acute Kidney Injury and Edaravone in Acute Ischemic Stroke: The Fukuoka Stroke Registry - Xavron\" \/>\n<meta property=\"og:description\" content=\"Background:\u00a0A free radical scavenger, edaravone, which has been used for the\u00a0treatment of ischemic stroke, was reported to cause acute kidney injury (AKI)\" \/>\n<meta property=\"og:url\" content=\"https:\/\/xavron.com.ua\/en\/publications\/gostre-poshkodzhennya-nyrok-i-edaravon-pry-gostromu-ishemichnomu-insulti-reyestr-insultu-fukuoka\/\" \/>\n<meta property=\"og:site_name\" content=\"Xavron\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-11T10:37:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/xavron.com.ua\/wp-content\/uploads\/2019\/07\/edaravon-i-gostra-nyrkova-nedostatnist.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"755\" \/>\n\t<meta property=\"og:image:height\" content=\"431\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/xavron.com.ua\\\/en\\\/publications\\\/gostre-poshkodzhennya-nyrok-i-edaravon-pry-gostromu-ishemichnomu-insulti-reyestr-insultu-fukuoka\\\/\",\"url\":\"https:\\\/\\\/xavron.com.ua\\\/en\\\/publications\\\/gostre-poshkodzhennya-nyrok-i-edaravon-pry-gostromu-ishemichnomu-insulti-reyestr-insultu-fukuoka\\\/\",\"name\":\"Acute Kidney Injury and Edaravone in Acute Ischemic Stroke: The Fukuoka Stroke Registry - 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