Neurological disorders in patients who had COVID-19: how to treat during a pandemic

The article provides an overview of the world literature data on lesions of the nervous system in patients who had COVID-19. The results of an open comparative study on the effectiveness of combined use of Xavron, Tivor-L and Xylat in patients with neurological disorders in the post-COVID period are also presented. The positive effect of the above combination of drugs on cognitive functions was demonstrated, which manifested itself in increasing the rate of mental activity, reducing the manifestations of the severity of asthenia, improved the indicators of the quality of life.

In post-COVID patients with neurological complications, serum levels of the pro-inflammatory marker cytokines IL-6 and VEGF were elevated. The addition of Xavron, Tivorel and Xylat to the basic therapy led to a decrease in the levels of IL-6 and VEGF, which suggests an anti-inflammatory effect of the proposed treatment regimen. The efficacy and safety of the syndromic-pathogenetic complex determines the prospects for its appointment for the treatment of patients with neurological post-COVID disorders.

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Keywords: COVID-19 pandemic; edaravone; neurological disorders; post-COVID; treatment; лікування

Authors: T.S. Mishchenko, V.M. Mishchenko V.V. Sokolik, A.V. Fisenko, I.V. Zdesenko V.N. Karazin Kharkiv National University, Kharkiv, Ukraine State Institution “Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine

Posted: International Neurological Journal, Volume 17, N 6, 2021