1. Why does Covid-19 activate a “cytokine storm”?

The main target of SARS-CoV-2 is lung epitheliocytes. The reaction of the immune system is accompanied by the release of a significant number of pro-inflammatory cytokines (IL-1, IL-6, IL-18, TNF-α) and the development of the so-called “cytokine storm”, which causes an extraordinary level of the inflammatory process.

  1. What is the “Khvileriz” scheme?

The infection of Covid-19 has a so-called wave-like course. The first wave is mild symptoms, after which there may be a period of temporary improvement, but then there is a second wave of symptoms, the pulmonary phase, which is more severe than the first. And in such a case, the main task of doctors is, so to speak, to “cut off” this wave and prevent the progression of lung tissue damage, in order to stabilize the patient’s condition, prevent its deterioration from progressing, that is, to try to prevent the development of a critical condition. It is expedient to appoint the so-called “Khvileriz”, the action of which is aimed at suppressing the cytokine storm.

  1. What awaits the patient if the “cytokine storm” is not extinguished?

The consequences are massive damage to the body’s target tissues: vascular endothelium, which causes systemic inflammation, violation of coagulation homeostasis, thromboembolism; lungs associated with the development of pneumonia and ARDS; cardiovascular system, which leads to the development of heart attacks, myocarditis and death, and others.

  1. What are the patient’s main symptoms for the use of the “Khvileriz” scheme?
  • Sick for more than 7 days, symptoms have not disappeared, loss of smell and taste (or distortion of taste).
  • The temperature is subfebrile, but there was a short-term rise above 38-39 ºС.
  • Ringing and tinnitus, headache, dizziness, dullness of thought, anxiety, apathy.
  • General blood test: a shift in the leukocyte formula – a significant increase in the percentage of lymphocytes; increase of erythrocytes and hemoglobin.
  • Respiratory insufficiency increases, saturation decreases.
  1. What are the possibilities of “Khvileriz” medical therapy?

💊 Edaravon (Xavron®) is a free radical scavenger that activates antioxidant defense enzymes, prevents the development of increased permeability of the endotheliocytes of the microcirculatory bed of the lungs, caused by pro-inflammatory cytokines, and is therefore useful for the treatment of patients with pneumonia and prevents the development of ARDS.

💊 The combination of L-carnitine and L-arginine (Tivorel®) helps to increase the content of NO in the lung tissue, which reduces the spasm of the non-striated muscles of the bronchi, improves the vasomotor function of the endothelium of the pulmonary arteries, and also plays an important role in cardiac metabolism and can alleviate the condition of patients with Covid-19 due to the immunomodulatory effect and inhibition of inflammatory mediators.

💊 Sorbitol-based solution (Rheosorbilact®) is a unique hyperosmolar crystalloid solution that improves microcirculation and tissue perfusion, helps correct metabolic acidosis, prevents the development of inflammatory reactions, and increases the body’s resistance to infections.