Methods of Correction of Neurological Disorders in Patients with Coronavirus Disease (COVID-19)

Eighty-three patients with coronavirus disease were examined at the Kharkiv Oblast Clinical Infectious Hospital and divided into groups depending on the therapy prescribed. In the main group, a syndromic-pathogenetic approach “Volnorez” was added to the baseline therapy. Against the background of treatment according to the scheme, which included edaravone, a combination of L-arginine and L-carnitine […]

Authors: Yurko E., Kucheryavchenko V., Solomennik A., Lesnaya A.

Posted: Clinical Infectiology and Parasitology, 2021, vol. 10, no. 2

At the forefront of the fight against COVID-19 – the experience of Ukrainian specialists (Video)

Doctors all over the world are still looking for and cannot find effective means to combat COVID-19. Therefore, every practical experience is invaluable. Let’s find out how Ukrainian doctors save the lives of the population. The latest experience was shared with leading domestic specialists in the framework of the reports of the IV International Congress […]

Posted: IV International Congress on Infusion Therapy (October 12-13, 2020)

Edaravone: A Free Radical Scavenger with Multiple Pleotropic Actions can be a Potential Game Changer Agent in Prevention and Alleviation of COVID-19 – Induced Cytokine Storm

Normal physiological process, such as cellular respiration generate small amount of oxidizing reactive oxygen species (ROS) and reactive nitrogen species (RNS). These free radicals play crucial role in activation of signalling pathways in animal and plant cells. These are chemically highly reactive molecules that can damage cell structures. However, there are endogenous defences (scavenger) or […]

Authors: Dr Butungeshwar Pradhan, Dr Gourav Pradhan, Deblina Pradhan

Posted: Journal of Medical Science and Clinical Research Vol 08, Issue 07, Page 227-236, July

Edaravone: A potential treatment for the COVID-19-induced inflammatory syndrome?

We read with great interest the recent article by Zhong et al. titled “Efficacy and Safety of Current Therapeutic Options for COVID-19 – Lessons to Be Learnt from SARS and MERS Epidemic: A Systematic Review and Meta-analysis [1],” which is the most complete review of randomized control trials and cohort studies of potential pharmacotherapies for […]

Authors: Sandra E. Reznik, Amit K. Tiwari, Charles R. Ashby Jr.

Posted: Pharmacological Research 160 (2020) 105055

Inhibitory Effects of Edaravone, a Free Radical Scavenger, on Cytokine-induced Hyperpermeability of Human Pulmonary Microvascular Endothelial Cells: A Comparison with Dexamethasone and Nitric Oxide Synthase Inhibitor

Lung hyperpermeability affects the development of acute respiratory distress syndrome (ARDS), but therapeutic strategies for the control of microvascular permeability have not been established. We examined the effects of edaravone, dexamethasone, and N-monomethyl-L-arginine (L-NMMA) on permeability changes in human pulmonary microvascular endothelial cells (PMVEC) under a hypercytokinemic state. Human PMVEC were seeded in a Boyden […]

Authors: Yukie Saitoa, Yousuke Fujii, Masato Yashiroa, Mitsuru Tsugea, Nobuyuki Nosakaa, Nobuko, Yamashitab, Mutsuko Yamadaa, Hirokazu Tsukaharaa, Tsuneo Morishimaa

Experience of using methods for syndromic and pathogenetic therapy in pneumonia caused by COVID-19 at the pulmonary department

The treatment of pneumonia caused by SARS-CoV-2 virus is extremely important today. Coronavirus disease (COVID-19) is a new infection, against which there are no specific drugs or vaccines. In many ways, its complications became unexpected. Leading experts believe that vaccines and/or special drugs for the treatment of SARS-CoV-2 infection will be developed in the nearest […]

Authors: S.V. Kovalenko

Posted: Medical newspaper "Health of Ukraine", № 13-14 (482-483), July 2020