При COVID-19

Ингибирующий эффект эдаравона, акцептора свободных радикалов, на повышенную проницаемость эндотелиоцитов микроциркуляторного русла легких, вызванную цитокинами: сравнение с дексаметазоном и ингибитором синтазы оксида азота

Автора: Рис. 8 Схематическая диаграмма, на которой изображена повышенная проницаемость легких, обусловленная TNF-a + IL-1 p и ингибирующее влияние эдаравона и дексаметазона.Таким образом, наши экспериментальные исследования показали, что эдаравон и дексаметазон могут предупредить развитие повышенной проницаемости в PMVEC человека, вызванной провоспалительными цитокинами, вероятно, в результате усиления адгезивных контактов и, не исключено, также за счет других меха­низмов (Рис. 8). Данные результаты могут внестиясность на клеточном и молекулярном уровне в стратегии лечения пациентов с ОРДС и пневмонией вследствие высокопатогенного гриппа птицы, приводящими к тяжелому поражению функции легких. Эдаравон и дексаметазон показали одинаковый эффект. 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